Andrographolide

Andrographolide ke sehlahisoa sa botanical se ntšitsoeng litlamang tse hlahang ka tlhaho Chaena.Setlama se na le histori e pharaletseng ea tšebeliso ea TCM bakeng sa phekolo ea mafu a ka holimo a matšoafo le mafu a mang a ho ruruha le a tšoaetsanoang.Andrographis paniculata e ile ea hlahisoa 'me ea lengoa Guangdong le Fujian e ka boroa ka 50s.E sebelisoa ho phekola mafu a fapaneng a tšoaetsanoang le ho longoa ke noha.Lilemong tsa morao tjena, temo, sebopeho sa lik'hemik'hale, pharmacology le likarolo tsa bongaka tsa Andrographis paniculata li 'nile tsa ithutoa Chaena.Andrographis paniculata ke moriana oa setso oa Machaena o sebelisoang hangata, o nang le litlamorao tsa ho tlosa mocheso le chefo, mali a pholileng le detumescence.Clinically, e haholo-holo sebelisoa bakeng sa ho phekoloa tshwaetso pampitšana ea ho hema, a hlobaetsang le bacillary lets'ollo, gastroenteritis, serame, feberu le kgatelelo ya madi.Ka keketseho ea tšebeliso e mpe ea lithibela-mafu le liketso tse mpe, lentsoe la ho nts'etsapele meriana ea setso ea Machaena e nang le phello e ntle ea antibacteria le ntse le eketseha.Andrographis paniculata, joalo ka moriana oa setso oa Machaena o nang le phello ea antibacteria, e lebisitsoe tlhokomelo e eketsehileng ke indasteri ea meriana.

Semela sa Andrographis paniculata se tsebahala hore se na le mesebetsi e fapaneng ea litlama.Andrographolide, e leng karolo ea mantlha ea moqomo, e ameha ts'ebetsong ea eona ea pharmacological.Re ithutile lits'ebetso tsa cellular le lipehelo tse fetotsoeng ke kalafo ea andrographolide mofetšeng oa motho le lisele tsa 'mele.Kalafo ea Andrographolide e thibetse ho ata ha in vitro ea lisele tse fapaneng tsa tumor, tse emelang mefuta e fapaneng ea mofets'e.Motsoako ona o fana ka ts'ebetso e tobileng ea anticancer liseleng tsa mofets'e ka ho ts'oaroa ha cell-cycle mohatong oa G0/G1 ka ho kenya protheine e thibelang li-cell-cycle inhibitory p27 le ho fokotseha ha polelo ea cyclin-dependent kinase 4 (CDK4).Mosebetsi oa immunostimulatory oa andrographolide o pakoa ke ho ata ha lymphocyte le tlhahiso ea interleukin-2.Andrographolide e boetse e ntlafalitse tlhahiso ea tumor necrosis factor-alpha le polelo ea letšoao la CD, e leng se bakileng keketseho ea ts'ebetso ea cytotoxic ea li-lymphocyte khahlano le lisele tsa mofetše, tse ka tlatsetsang ts'ebetsong ea eona e sa tobang ea anticancer.Ts'ebetso ea in vivo anticancer ea komporo e netefatsoa hape khahlano le mefuta ea B16F0 melanoma syngenic le HT-29 xenograft.Liphetho tsena li fana ka maikutlo a hore andrographolide ke pharmacophore e khahlisang e nang le ts'ebetso ea anticancer le immunomodulatory mme ka hona e na le monyetla oa ho ntlafatsoa joalo ka moemeli oa kalafo ea mofets'e.